Professor Sir Richard Peto
“Basically, if trials are going to be done there are lots and lots of questions that could be answered by trials and should be answered by trials and will not be answered by trials unless we reduce the regulatory burden on trials”
Professor Rob Califf commenting on randomised trials
“I think it is god’s gift”
“I’m seeing that in Silicon Valley big time,
because it still seems very strange to me that the dominant companies today in the global marketplace,
think it would be crazy to make a major business decision to do something without randomising it to make sure you are making the right decision.”
“Yet there we are with people’s health,
the most precious thing,
and we are just guessing a very high proportion of the time, when given the magnitude of the data available we could know if we randomised within the real-world.”
Professor Salim Yusuf on ICH-GCP training
“They have also led to a large number of courses focused on the regulations and those who complete them have a mistaken belief that they are capable of running trials, but often have little knowledge of the scientific underpinnings of randomised trials.
This is wasteful, and may even be harmful”
Professor Martin Landray
“Fundamentally, only two things really matter when doing a randomised trial. First, look after the safety and wellbeing of the people who take part and second, make sure the trial produces a reliable result for the benefit of future patients”
Professor PJ Devereaux
“Imagine creating a regulation for putting out fires and forgetting to ask firefighters for their input. Sounds absurd, I know, but that’s exactly what we’ve done in regulating trials by not involving trialists”
Professor Sir Rory Collins
“Randomised trials might well be one of the most important scientific discoveries of the 20th century, but we should ask ourselves, if randomised trials were invented today would we do them like this?”
